Already deemed a top 5 moment in Mike'd Ups' existence, here is the clip (a clearer version can be found here) of Larry from Connecticut, who was on the verge of winning it all when the phones suddenly went:
I love the fact that Mike went from extreme-diarrhea mode to making a face which I absolutely love.
I didn't think he was capable of making a genuine expression like that. I guess he's human after all. For now.